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TLR7 signaling aggravates lung inflammation associated with increased anti-Scl-70 autoantibody production in murine bleomycin-induced systemic sclerosis

Abstract: Systemic sclerosis (SSc) is a severe autoimmune disease characterized by immune dysregulation, fibrosis, and substantial morbidity and mortality. Although type I…

Date: 2026-07-01

Immune profiling shows limited systemic changes in children with autism after autologous cord blood transfusion

Abstract: Autism spectrum disorder (ASD or autism) is a neurodevelopmental condition characterized by social difficulties and restricted, repetitive behaviors, and is a leading…

Date: 2026-07-01

Differential generation of parasite-specific Th2 and T follicular helper cells distinguishes resistant and susceptible mouse strains

Abstract: Both T helper 2 (Th2) and B cell responses are crucial for controlling gastrointestinal (GI) nematode infections. However, adaptive immune determinants of host…

Date: 2026-07-01

LAG3-centered multiplex immune profiling as a prognostic biomarker in hepatocellular carcinoma patients receiving Anti-PD-1 antibodies plus lenvatinib therapy

Abstract: This study aims to investigate the characteristics and functional status of the lymphocyte-activation gene-3 (LAG-3), cluster of differentiation 8 (CD8), programmed cell…

Date: 2026-07-01

Predicting overall survival in synchronous metastatic nasopharyngeal carcinoma using a stacking ensemble machine learning model: a multicenter retrospective study

Abstract: Patients with synchronous metastatic nasopharyngeal carcinoma (smNPC) show marked survival heterogeneity, which complicates individualized prognostic assessment and…

Date: 2026-07-01

Impact of RAS mutation status on early progression in patients with initially unresectable colorectal liver metastases undergoing conversion therapy: a retrospective analysis

Abstract: Colorectal cancer liver metastases (CRLM) frequently recur or progress after systemic and local treatment, particularly in patients with initially unresectable disease.…

Date: 2026-07-01

Tumor microenvironment-oriented HNGCIscore identifies immunotherapy-sensitive subgroups in ICI retreatment of HER2-negative advanced gastric cancer

Abstract: PD-1/PD-L1 inhibitor-based chemoimmunotherapy has become a standard first-line treatment for HER2-negative advanced gastric or gastro-esophageal junction cancer.…

Date: 2026-07-01

Association between frailty and breast cancer incidence and construction of a breast cancer prediction model based on machine learning

Abstract: The relationship between frailty and breast cancer (BC) has been scarcely investigated. This study aims to explore the association between frailty and BC and to develop…

Date: 2026-07-01

Women’s experiences and perspectives on a nurse navigation program for cervical cancer screening: a qualitative study

Abstract: Cervical cancer remains an important public health problem despite the availability of effective screening and prevention strategies. Psychosocial, individual, and…

Date: 2026-07-01

The characteristics and clinical outcomes of atrial fibrillation patient in middle income country of Indonesia

Abstract: Atrial fibrillation (AF) is an increasing health concern in Asia, but data from developing countries remain scarce. Although direct oral anticoagulants (DOACs) are now…

Date: 2026-07-01