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Comparison of clinical and laboratory characteristics of neuromyelitis optica spectrum disorder with or without anti-connective tissue antibodies: an 18-month cohort follow-up

Abstract: This study aimed to explore the significance of anti-connective tissue antibodies in the clinical diagnosis and evaluation of neuromyelitis optica spectrum disorder…

Date: 2026-06-19

Plasma metabolomic signatures of the no-reflow phenomenon in stroke patients following thrombectomy

Abstract: Although successful recanalization of the occluded artery is achieved, no-reflow phenomenon (NRP) becomes a main contributor to poor prognosis in patients with acute…

Date: 2026-06-19

A self-perpetuating neuron-intrinsic GSDMD–mtDNA–AIM2 inflammasome axis drives neuronal pyroptosis and cognitive impairment after traumatic brain injury

Abstract: Traumatic brain injury (TBI) is a leading cause of mortality and long-term disability worldwide, producing acute neurological deficits and lasting cognitive impairment.…

Date: 2026-06-19

Neonatal CD19 + B220 lo cells sense microbiota via TLR2/4 activation driving proliferation and differentiation

Abstract: Neonatal respiratory infections remain a leading cause of mortality and morbidity worldwide, yet there is still little information about the role of B cell populations…

Date: 2026-06-19

Efficacy and safety of stereotactic radiotherapy in patients with HER2-positive breast cancer brain metastases following intracranial oligoprogression

Abstract: Tyrosine kinase inhibitors (TKIs) demonstrate clear therapeutic effects in patients with HER2?positive breast cancer complicated by brain metastases. However, the…

Date: 2026-06-19

Proteasome inhibition induces a BRCAness-like state and sensitises HR-proficient ovarian cancer models to PARP inhibitors

Abstract: Poly (ADP-ribose) polymerase inhibitors (PARPi) have improved outcomes in ovarian cancer with homologous recombination deficiency (HRD). However, approximately half of…

Date: 2026-06-19

Single dose of 5 Gy can damage erythrocytes and consequently induces lymphocyte depletion in spleen and circulating blood

Abstract: Radiation-induced lymphopenia (RIL) has been well known to associate with poor patient prognosis. Based on interesting findings in our previous study, we hypothesize…

Date: 2026-06-19

Quality and reliability of cardiac rehabilitation-related short Chinese videos on Douyin and Bilibili: a cross-sectional content analysis

Abstract: Social media platforms have emerged as prominent channels for disseminating cardiovascular health information. However, the accuracy, completeness, and clinical…

Date: 2026-06-19

“Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk”

Abstract: Pericoronary adipose tissue (PCAT) attenuation is a non-invasive imaging marker of coronary vascular inflammation. However, its relationship with clinical outcomes and…

Date: 2026-06-19

Immunotherapy with or without low-intensity chemotherapy versus conventional chemotherapy as first-line treatment for newly diagnosed B-ALL patients fit for intensive chemotherapy: a propensity score-matched study

Abstract: For B-cell acute lymphoblastic leukemia (B-ALL), the dominance of traditional chemotherapy is being rewritten, with multiple promising novel treatment approaches…

Date: 2026-06-18