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Obinutuzumab versus rituximab-based chemotherapy in high-tumor burden indolent B-cell lymphoma: a real-world comparative study

Abstract: Patients with previously untreated follicular lymphoma (FL) or marginal zone lymphoma (MZL) with high-tumor burden represent a subset with unfavorable prognosis.…

Date: 2026-06-18

Estimated five-year survival and direct healthcare costs of adult patients with gastric cancer: real-world evidence from a tertiary hospital in Colombia

Abstract: Gastric cancer remains a major cause of cancer mortality worldwide, particularly in middle-income countries, where late diagnosis is frequent and information on its…

Date: 2026-06-18

Real-world effectiveness and safety of carfilzomib, pomalidomide, and dexamethasone in relapsed/refractory multiple myeloma: a retrospective analysis from China

Abstract: Pomalidomide, a next-generation immunomodulatory drug (IMiD), and carfilzomib, a novel proteasome inhibitor (PI), have been separately approved in combination regimens…

Date: 2026-06-18

A novel inflammatory-nutritional index: NPAR-correlates with the severity of type 2 diabetic foot ulcers

Abstract: The neutrophil-percentage-to-albumin ratio (NPAR), an inflammatory-nutritional biomarker, has prognostic value in various diseases, but its relationship with DFU…

Date: 2026-06-18

Diagnostic value of tubular and glomerular biomarkers across different stages of kidney injury in patients with type 2 diabetic nephropathy

Abstract: Diabetic nephropathy (DN) remains a major cause of chronic kidney disease in patients with type 2 diabetes mellitus (T2DM), yet conventional markers incompletely capture…

Date: 2026-06-18

Acute glucose stimulation drives coordinated translational reprogramming in primary pancreatic islets: from global remodeling to fine-tuned insulin synthesis

Abstract: Pancreatic beta cells must rapidly escalate protein synthesis to maintain systemic glucose homeostasis. While the transcriptional responses are well characterized, the…

Date: 2026-06-18

The levels of vascular endothelial cells and endothelium-dependent vasomotor cytokines in children with essential hypertension: a case-control study

Abstract: Circulating endothelial cells (CECs), endothelial progenitor cells (EPCs) and endothelium-dependent vasomotor cytokines are important in maintaining endothelial function…

Date: 2026-06-18

Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study

Abstract: To investigate the association between glucolipid metabolic indicators and suspected precocious puberty (PP) in children living with obesity. This retrospective…

Date: 2026-06-18

Identifying predictors of use of mental health services and supports during the COVID-19 pandemic: an analysis of the CHILD COVID-19 Add-on Study

Abstract: The aim of this work was to explore the rate of and factors associated with the use of mental health services and supports (MHSS) in a Canadian cohort of children and…

Date: 2026-06-18

Impact of high disease activity on damage accrual and disease outcomes in childhood-onset systemic lupus erythematosus

Abstract: The impact of the duration and cumulative high disease activity on damage accrual in childhood-onset SLE (cSLE) is less well established. This study aimed to assess the…

Date: 2026-06-18