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Effects of parthenolide on amino acid metabolism and oxidative stress in lung adenocarcinoma based on quantitative proteomic analysis, targeted amino acid metabolomics, network pharmacology, and experimental validation

Abstract: Lung adenocarcinoma (LUAD) causes millions of deaths annually worldwide. Parthenolide (PTL), extracted from traditional Chinese herbal medicines, has various biological…

Date: 2025-09-01

Clinical value at baseline and follow-up of myeloperoxidase-antibodies in ANCA-associated vasculitis

Abstract: ANCA-associated vasculitides (AAV) are potentially organ- or life-threatening disorders that can cause irreversible damage if treatment is not started in time. The…

Date: 2025-09-01

Patient satisfaction and pain relief following radiofrequency rhizotomy for trigeminal neuralgia: a prospective cohort study

Abstract: Trigeminal neuralgia (TN) causes severe facial pain and affects quality of life. Radiofrequency rhizotomy (RFR) is often used when medications fail. This multicenter…

Date: 2025-09-01

Acute effects of Tai Chi with different practice emphasis on autonomic activity

Abstract: Exercise intensity, breathing patterns, and intentional meditation significantly influence autonomic nervous system activity. Tai Chi serves as an aerobic exercise…

Date: 2025-09-01

Image steganalysis using LSTM fused convolutional neural networks for secure telemedicine

Abstract: Deep learning-based image steganalysis has progressed in recent times, with efforts more concerted toward prioritizing detection accuracy over lightweight frameworks. In…

Date: 2025-09-01

Risk factors for acute kidney injury in patients with acute pancreatitis and construction of nomogram model: a single-center study and external validation

Abstract: This study aims to utilize clinical data from patients with acute pancreatitis (AP) recorded in the MIMIC-IV database to analyze the risk factors associated with acute…

Date: 2025-09-01

The association of diabetic retinopathy and diabetic kidney disease in patients with type 2 diabetes mellitus: a prospective observational research study

Abstract: Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are two prevalent diabetic complications significantly influencing global health and quality of life.…

Date: 2025-09-01

Optimal l -arginine dosage for pressure injury healing in home care settings: a six-month retrospective analysis

Abstract: Pressure injuries present a significant challenge for patients receiving home care, particularly those with limited mobility. Although l -arginine supplementation has…

Date: 2025-09-01

Chain-mediated pathways of adults socioeconomic status affecting physical fitness in Macao: the role of motor skills and moderate to vigorous physical activity

Abstract: To investigate the relationship between adults’ socioeconomic status and physical fitness, and the chain mediation effects of motor skills and moderate to vigorous…

Date: 2025-09-01

Expression of cyclooxygenase-2 and smooth muscle actin biomarkers in different subtypes of basal cell carcinoma

Abstract: Basal cell carcinoma (BCC) is the most common form of skin cancer, with diverse subtypes and UV radiation as a major risk factor. Key markers like COX-2 and smooth…

Date: 2025-09-01