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Transforming growth factor-? superfamily members as potential biomarkers for adolescent major depressive disorder

Abstract: Growing evidence implicates the transforming growth factor-? (TGF-?) superfamily in neurodevelopment and immunoregulatory processes, with several members associated with…

Date: 2025-09-01

The role of ZC3H13 in promoting M2 macrophage infiltration via m6A methylation in esophageal squamous cell carcinoma tumor progression

Abstract: ZC3H13 (zinc finger CCCH-type containing 13) is a member of the zinc finger protein family with regulatory roles in gene expression and represents a crucial m6A…

Date: 2025-09-01

A qualitative examination of the evolving role of sports technology in collegiate coaching

Abstract: Coaches play a central role in shaping athlete performance and development. In collegiate sports, coaches must balance competitive goals with the broader needs of…

Date: 2025-09-01

Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology

Abstract: Influenza A virus (IAV) infection is associated with high morbidity and mortality and can ultimately lead to acute lung injury (ALI). In traditional Chinese medicine,…

Date: 2025-09-01

Profiling learning approaches among Saudi postgraduate medical trainees: advancing education in the Vision 2030 era

Abstract: Understanding learning approaches among postgraduate clinical trainees is essential for shaping educational policies that align with Saudi Arabia’s Vision 2030 and its…

Date: 2025-09-01

Intraplacental choriocarcinoma and spontaneous fetomaternal hemorrhage: Uncovering diagnostic clues in a challenging case

Abstract: Intraplacental choriocarcinoma (IC) is an extremely rare malignancy of the placenta that is often associated with fetomaternal hemorrhage (FMH). This combination is…

Date: 2025-09-01

Ghrelin’s potential as a therapeutic target for chronic inflammatory diseases: evidence from human endometrial stromal cells

Abstract: Ghrelin, a peptide composed of 28 amino acids, is recognized for its role in regulating appetite and energy balance. Recently, it has also been identified as an…

Date: 2025-09-01

Evaluating the toxicity profile of combination immune checkpoint inhibitors: a disproportionality analysis of real-world adverse events from the FDA Adverse Event Reporting System for tremelimumab, durvalumab, ipilimumab, and nivolumab

Abstract: As one of the therapeutic modalities for treating tumors, immune checkpoint inhibitors (ICIs) have gained widespread application in clinical practice, including…

Date: 2025-09-01

Cognitive effort devaluation and the salience network: a computational model of amotivation in depression

Abstract: Amotivation in depression is linked to impaired reinforcement learning and effort expenditure via the dopaminergic reward pathway. To understand its computational and…

Date: 2025-09-01

Mental health consequences for adolescents during the Russian invasion of Ukraine: protocol for the Ukraine Adolescent Mental Health Study

Abstract: In February 2022, Russia launched a full scale-invasion of Ukraine, which is the largest European ground offensive since the Second World War. However, the…

Date: 2025-09-01