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Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes

Abstract: Background and aims: Immunologically hot tumors, characterized by an inflamed tumor microenvironment (TME), contrast significantly with immunologically cold tumors. The…

Date: 2025-01-22

HIV-related stigma among young men who have sex with men in HIV care in Plateau State Nigeria

Abstract: Background: HIV-related stigma is often expressed as irrational behaviors, negative attitudes, and unfavorable judgments toward people living with or at risk of HIV…

Date: 2025-01-22

Clinical burden of obstructive hypertrophic cardiomyopathy in France

Abstract: Background: Hypertrophic cardiomyopathy (HCM) can be genetic and occurs as obstructive and non-obstructive 21 subtypes. Little is known about the clinical burden of the…

Date: 2025-01-22

Cardiovascular toxicity of tisagenlecleucel in children and adolescents: analysis of spontaneous reports submitted to FAERS

Abstract: Background: The advent of tisagenlecleucel has been a major advance in the pharmacological treatment of relapsed/refractory B-cell acute lymphoblastic leukemia in…

Date: 2025-01-22

Association between triglyceride-glucose index and all-cause mortality in critically ill patients with acute myocardial infarction: analysis of the MIMIC-IV database

Abstract: Background: Currently, the clinical evidence regarding the prognostic significance of the TyG index in acute myocardial infarction (AMI) patients remains unclear. Our…

Date: 2025-01-22

Prognostic value of inflammatory markers for all-cause mortality in patients with acute myocardial infarction in the coronary care unit: a retrospective study based on MIMIC-IV database

Abstract: Background: Acute myocardial infarction (AMI) is prevalent and perilous, leading to mortality and disability in the coronary care unit (CCU). This paper was to verify…

Date: 2025-01-22

Knowledge, attitudes and practice toward refractive errors management among left-behind children of migrant workers

Abstract: Background: This study aimed to access knowledge, attitudes and practice (KAP) regarding refractive errors (RE) management among the left-behind children of migrant…

Date: 2025-01-21

Low back pain trends attributable to high body mass index over the period 1990–2021 and projections up to 2036

Abstract: Background: High body mass index (BMI) is a crucial determinant in low back pain (LBP) incidence and progression. However, the effect of increased BMI on LBP has been…

Date: 2025-01-21

Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function

Abstract: Background: Oral probiotic dietary supplements are widely used in veterinary medicine, including in horses. It is hypothesized that the presence of probiotic strains can…

Date: 2025-01-21