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Navigating the diagnostic challenges of myoclonus in neurodegenerative disorders: video-EEG/polygraphy, clinical vignettes, and narrative analysis

Abstract: Myoclonus—sudden, brief, involuntary muscle jerks—is a frequent and diagnostically challenging feature across neurodegenerative disorders. Unlike epileptic myoclonus,…

Date: 2025-09-12

Tracking prodromal Parkinson’s disease: a five-year follow-up of the PARCAS cohort

Abstract: The updated International Parkinson and Movement Disorders Society (MDS) research criteria for prodromal Parkinson’s disease (pPD) enable pPD probability assessment. In…

Date: 2025-09-12

Transradial approach in vertebral artery stenting

Abstract: The transradial approach (TRA) has been gaining attraction for endovascular procedures. This study aimed to compare the efficacy and safety of the TRA vs. the…

Date: 2025-09-12

Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults

Abstract: In Ghana, at least five different COVID-19 vaccines based on mRNA or adenovirus vector delivery platforms have been authorized by the Ghana Health Service for…

Date: 2025-09-12

The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways

Abstract: Immunosuppressive factors within the tumor microenvironment hinder effective antitumor immune responses and limit the efficacy of current immunotherapies.…

Date: 2025-09-12

Association of dietary fiber intake with all-cause and cardiovascular mortality in U.S. adults with metabolic syndrome: NHANES 1999–2018

Abstract: Low dietary fiber intake is common in the US, despite its health benefits. Individuals with metabolic syndrome (MetS), at high cardiovascular risk, may benefit…

Date: 2025-09-11

Safety assessment of gemtuzumab ozogamicin: real-world adverse event analysis based on the FDA Adverse Event Reporting System

Abstract: To mine adverse drug events (ADEs) following the use of gemtuzumab ozogamicin based on the FDA Adverse Event Reporting System (FAERS), and to provide references for the…

Date: 2025-09-11

Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet

Abstract: Brown adipose tissue (BAT) is crucial for overall energy homeostasis as a thermogenic organ with high metabolic activity. While the recruitment of BAT contributes to…

Date: 2025-09-11

Comparison of children with bioinactive growth hormone, small for gestational age, and idiopathic short stature

Abstract: Short stature has many causes, including rare disorders of GH function. Bioinactive growth hormone (GH) refers to a phenotype characterized by immunoreactive but…

Date: 2025-09-11

Endocrine complications after solid organ transplantation in childhood and adolescents

Abstract: Acute or chronic metabolic derangement following solid organ transplantation (SOT) often leads to endocrine complications, which have become more common as survival…

Date: 2025-09-11