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Minimally expanded breast cancer tumor-infiltrating-lymphocytes provide guidance for therapeutic selection

Abstract: The analysis of tumor-infiltrating lymphocytes often requires techniques that expand their numbers, potentially introducing bias. To address this, we performed a…

Date: 2025-11-27

Immune responses in pulmonary sarcoidosis following COVID-19

Abstract: The complex interplay between sarcoidosis and COVID-19 remains an important area of research, since COVID-19 leads to long-term changes in the immune system. However,…

Date: 2025-11-27

Anti-HER2/neu TCR-T Cells in Action: linking transcriptional signatures, secretomics, and In Vivo tumor suppression

Abstract: T cell receptor-engineered T cell therapy has emerged as a promising approach in cancer immunotherapy, leveraging the ability of T cells to recognize tumor antigens…

Date: 2025-11-27

IgA expressed by glomerular mesangial cells is involved in the pathogenesis of IgA nephropathy

Abstract: The widely accepted “multi-hit hypothesis” of IgAN pathogenesis was challenged, as efficient depletion of CD20+ B cells failed to reduce serum galactose-deficient IgA1…

Date: 2025-11-27

Co-existence of chronic spontaneous urticaria with atopic dermatitis: clinical and immunological perspectives

Abstract: Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD) are both immune-mediated inflammatory skin disorders that often co-exist with other atopic conditions such…

Date: 2025-11-27

NETs promote invasive behavior of fibroblast-like synoviocytes through GPIb? in rheumatoid arthritis

Abstract: Neutrophil extracellular traps (NETs) have been implicated in rheumatoid arthritis (RA) pathogenesis, yet their effects on fibroblast-like synoviocytes (FLS) remain…

Date: 2025-11-27

Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire

Abstract: Healthcare workers in resource-limited settings are frequently exposed to SARS-CoV-2, often with incomplete vaccine coverage. Yet, their adaptive immune responses remain…

Date: 2025-11-27

Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis

Abstract: Ionizing radiation causes immune dysfunction, increasing susceptibility to infection and mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) is released…

Date: 2025-11-27

Low lymphozyte pool, colon perforation and hydrocephalus as clinical features in an infant with a postzygotic PIK3CA variant

Abstract: Pathogenic variants in the PIK3CA gene, which encodes the p110-? catalytic subunit of the phosphoinositide 3-kinase (PI3K), are commonly associated with overgrowth…

Date: 2025-11-27

The recombinant IL-35 and anti-Ebi3 antibody administration before implantation modulate immune regulation and fetal outcomes in an abortion-prone mouse model

Abstract: Interleukin-35 (IL-35), consisting of two subunits - Ebi3 and p35, is a pleiotropic anti-inflammatory cytokine implicated in fetal tolerance and pregnancy maintenance.…

Date: 2025-11-27