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Pharmacovigilance-based 12-year post-marketing safety analysis of quadrivalent influenza vaccines in children: a VAERS surveillance study

Abstract: Quadrivalent influenza vaccines (QIVs) are extensively administered to children for seasonal influenza prevention. However, comprehensive long-term evaluations of…

Date: 2025-09-02

Counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes treated with tirzepatide

Abstract: To evaluate counterregulatory hormonal responses during a hypoglycemic clamp with tirzepatide. Participants with type 2 diabetes (N=42) were randomized to tirzepatide…

Date: 2025-09-02

Dysregulated tryptophan metabolism: driving T cell subsets and PI3K-Akt pathway alterations in Hashimoto’s thyroiditis

Abstract: This study explored the role of tryptophan (Trp) metabolism in Hashimoto’s thyroiditis (HT) pathogenesis using clinical samples and animal models, given the unclear…

Date: 2025-09-02

The biological and immunological significance of the estrogen-related gene IER3 in diabetes

Abstract: Diabetes Mellitus (DM) is a complex metabolic disorder characterized by hyperglycemia, primarily arising from insufficient insulin secretion or the development of…

Date: 2025-09-02

Autoimmune encephalitis in Latin America. Clinical features and outcomes in pediatric and adult populations: retrospective cohort of The REAL LABIC Project

Abstract: The Autoimmune Encephalitis Registry in Latin American countries (REAL LABIC Project) is an initiative created to conduct research focused on the epidemiological and…

Date: 2025-09-02

Lipid biomarkers of GVHD in allogeneic stem hematopoietic cell transplantation patients

Abstract: While dyslipidemia is established as a key modulator of innate and adaptive immune responses, its role in hematopoietic reconstitution remains unclear. This study aimed…

Date: 2025-09-02

Distribution of microsporidia in preterm and full-term infant gut microbiomes and implications for host health

Abstract: Microsporidia are a group of single-celled fungi which infect various chordates including humans, where they mainly pose a risk to immunocompromised individuals. This…

Date: 2025-09-02

Experiences with complementary and integrative medicine in mental healthcare: a qualitative substudy of the PSYKIM project

Abstract: Complementary and integrative medical procedures (CIM) are commonly used in Germany, including for the treatment of mental health conditions. The aim of the study was to…

Date: 2025-09-02

Clinical experience and perception of risk affect the acceptance and trust of using AI in medicine

Abstract: As Artificial Intelligence (AI) is progressively making inroads into clinical practice, questions have arisen as to whether acceptance of AI is skewed towards certain…

Date: 2025-09-02

Development and validation of a triglyceride-glucose integrated nomogram for acute kidney injury prediction in acute myocardial infarction patients: a multicenter database study

Abstract: Acute kidney injury (AKI) is a life-threatening complication in patients with acute myocardial infarction (AMI), leading to increased morbidity and mortality. Early…

Date: 2025-09-02