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Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology

Abstract: Influenza A virus (IAV) infection is associated with high morbidity and mortality and can ultimately lead to acute lung injury (ALI). In traditional Chinese medicine,…

Date: 2025-09-01

Profiling learning approaches among Saudi postgraduate medical trainees: advancing education in the Vision 2030 era

Abstract: Understanding learning approaches among postgraduate clinical trainees is essential for shaping educational policies that align with Saudi Arabia’s Vision 2030 and its…

Date: 2025-09-01

Intraplacental choriocarcinoma and spontaneous fetomaternal hemorrhage: Uncovering diagnostic clues in a challenging case

Abstract: Intraplacental choriocarcinoma (IC) is an extremely rare malignancy of the placenta that is often associated with fetomaternal hemorrhage (FMH). This combination is…

Date: 2025-09-01

Ghrelin’s potential as a therapeutic target for chronic inflammatory diseases: evidence from human endometrial stromal cells

Abstract: Ghrelin, a peptide composed of 28 amino acids, is recognized for its role in regulating appetite and energy balance. Recently, it has also been identified as an…

Date: 2025-09-01

Evaluating the toxicity profile of combination immune checkpoint inhibitors: a disproportionality analysis of real-world adverse events from the FDA Adverse Event Reporting System for tremelimumab, durvalumab, ipilimumab, and nivolumab

Abstract: As one of the therapeutic modalities for treating tumors, immune checkpoint inhibitors (ICIs) have gained widespread application in clinical practice, including…

Date: 2025-09-01

Cognitive effort devaluation and the salience network: a computational model of amotivation in depression

Abstract: Amotivation in depression is linked to impaired reinforcement learning and effort expenditure via the dopaminergic reward pathway. To understand its computational and…

Date: 2025-09-01

Mental health consequences for adolescents during the Russian invasion of Ukraine: protocol for the Ukraine Adolescent Mental Health Study

Abstract: In February 2022, Russia launched a full scale-invasion of Ukraine, which is the largest European ground offensive since the Second World War. However, the…

Date: 2025-09-01

Multi-informant measurement of social anxiety symptoms in youth with social anxiety with and without autism

Abstract: Discrepancies between caregiver and youth report of social anxiety symptoms persist, yet measuring social anxiety symptoms, particularly among autistic youths, is…

Date: 2025-09-01

Reversed sex disparities in heart failure mortality in Spain, 2000–2023: a population-based analysis of older adults

Abstract: Heart failure (HF) is a growing public health concern in Spain, ranking as the third leading cause of cardiovascular mortality and contributing substantially to…

Date: 2025-09-01

Whole mitochondrial genome sequencing in individuals with Leber hereditary optic neuropathy negative for the common pathogenic mitochondrial DNA variants

Abstract: This study aimed to explore the role of additional mitochondrial DNA (mtDNA) variants in the development of Leber hereditary optic neuropathy (LHON) by screening the…

Date: 2025-09-01