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A prospective pilot study on plasma amyloid beta oligomers and postoperative delirium

Abstract: Postoperative delirium (POD) is common in older adults and has been linked to Alzheimer’s disease (AD). Plasma amyloid-? oligomers (A?Os) may clarify this relationship.…

Date: 2025-10-27

AI-assisted peripheral immune profiling reveals unconventional lymphocyte signatures associated with prognosis in soft tissue sarcoma patients

Abstract: Immunotherapy has reshaped the treatment of several cancers, yet patient responses remain highly variable, partly due to differences in immune competence. In soft tissue…

Date: 2025-10-27

Stepwise development of an implementation protocol to support the prescription of Exercise?=?Medicine by clinicians using the Implementation Mapping approach

Abstract: Several barriers, such as lack of time, knowledge and support, hinder clinicians from providing an individually tailored physical activity (PA) prescription and referral…

Date: 2025-10-27

Association between CT-derived skeletal muscle and fat indices and fracture healing following operative treatment for intertrochanteric fractures: a multicenter retrospective study

Abstract: Intertrochanteric fractures account for nearly 50% of hip fractures in elderly patients and are primarily treated with internal fixation. Considerable variability in…

Date: 2025-10-27

Artemisia absinthium L. ethanol extract inhibits the growth of gastrointestinal cancer cells by inducing apoptosis and mitochondria-dependent pathway

Abstract: Artemisia absinthium L. has a long history in the treatment of gastrointestinal cancer (GIC), but its molecular mechanisms remain unclear. We identified and validated…

Date: 2025-10-27

Retrospective analysis of 11 patients with ipsilateral hemiplegia caused by acute cerebral infarction

Abstract: To summarize the clinical and imaging characteristics of patients with ipsilateral hemiparesis caused by acute cerebral infarction, and to explore possible…

Date: 2025-10-27

Effect of age on the efficacy and safety of clopidogrel plus aspirin vs aspirin alone in acute mild-to-moderate stroke: a secondary analysis of the ATAMIS trial

Abstract: The association between age and the effect of antiplatelet therapy on clinical outcomes in patients with ischemic stroke remains unclear. This study aimed to explore the…

Date: 2025-10-27

Factors influencing health behavior changes in people with early multiple sclerosis: process evaluation of the multicenter randomized controlled POWER@MS1 trial

Abstract: Health behavior changes, i.e., optimizations of physical activity, diet, sleep and stress management, are increasingly considered as modifiers of prognostic risk in…

Date: 2025-10-27

Elevated IL-6, IL-10, and IFN-? levels in fatal elephant endotheliotropic herpesvirus – hemorrhagic disease cases suggest an excessive proinflammatory cytokine response contributes to pathogenesis

Abstract: Hemorrhagic disease developed as a consequence of an EEHV infection (EEHV-HD) is the leading cause of death of young Asian elephants in Zoos worldwide and also affects…

Date: 2025-10-27

Engineered multifunctional transforming growth factor-? type II receptor ectodomain fusions for oncology applications

Abstract: The transforming growth factor-? (TGF-?) superfamily consists of a large number of evolutionarily conserved and structurally related polypeptide growth factors. TGF-?…

Date: 2025-10-27