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HOXA5-mediated spatial remodeling of tumor-immune interfaces across cancers promotes AML pathogenesis

Abstract: HOXA5 (homeobox A5) exhibits context-dependent roles in cancer, but its pan-cancer spatial immune regulatory functions and therapeutic potential remain poorly…

Date: 2025-10-23

Benralizumab for adults with rare and off-label eosinophilic disorders: a 52-week prospective, single-center study

Abstract: Rare eosinophilic disorders are challenging to manage due to their heterogeneity and lack of targeted therapies. Benralizumab, an anti-IL-5 receptor monoclonal antibody…

Date: 2025-10-23

Exploratory investigation of dose calculation and tumor-feeding artery identification using dual CBCT in selective internal radiation therapy with Yttrium-90 microspheres

Abstract: To explore the preliminary application of dual cone-beam CT (CBCT) for dose calculation and tumor-feeding arteries identification in 90 Y-SIRT planning. A retrospective…

Date: 2025-10-23

Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma

Abstract: We have previously shown inhaled IL-15 is associated with anti-tumor responses in dogs with metastatic osteosarcoma (OSA) and melanoma. We evaluated inhaled IL-15…

Date: 2025-10-23

Information needs and barriers to patient-centered care in oncology: EtnobreastHER2, an ethnographic study with HER2+ MBC patients and their healthcare providers

Abstract: Qualitative evidence regarding the structural barriers embedded in healthcare ecosystems impacting Human Epidermal Growth Factor Receptor 2 metastatic breast cancer…

Date: 2025-10-23

Target vessel–specific efficacy and short-term outcomes of rotational atherectomy in the treatment of chronic total occlusion

Abstract: To compare the procedural features, treatment efficacy, and short-term outcomes of RA for CTO in different target vessels—LAD, LCX, and RCA—and to assess the anatomical…

Date: 2025-10-23

From patterns to prognosis: machine learning–derived clusters in advanced heart failure

Abstract: Advanced heart failure (HF) is a clinically heterogeneous condition with poor prognosis, and traditional classification systems often fail to capture the complexity…

Date: 2025-10-23

Association between the platelet-albumin-bilirubin score and all-cause mortality in ICU-admitted heart failure patients: a retrospective cohort analysis and machine learning-based prognostic modeling

Abstract: The platelet-albumin-bilirubin (PALBI) score has shown prognostic value across multiple medical conditions; nevertheless, its effectiveness in forecasting prognoses…

Date: 2025-10-23

Identification and validation of plasma protein biomarkers as therapeutic targets in acute myeloid leukemia: an integrative multi-omics study

Abstract: Acute myeloid leukemia (AML) remains a therapeutic challenge due to its high relapse rate and limited treatment options. This study aimed to identify and validate novel…

Date: 2025-10-22

Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice

Abstract: Atopic Dermatitis (AD), a chronic inflammatory skin disease characterized by pruritus, dryness, redness, edema, scratching, and lichenification, ranks as the leading…

Date: 2025-10-22