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Analysis of intestinal microorganisms and metabolite in childhood allergic asthma: role in assessing the severity of condition in children

Abstract: Childhood allergic asthma is a widespread chronic respiratory condition that is becoming more common worldwide. Presently, the evaluation of its severity depends on…

Date: 2025-12-11

Identification of novel variants underlying non-syndromic primary ovarian insufficiency using a targeted NGS gene panel

Abstract: Primary ovarian insufficiency (POI) affects 1-4% of women and is associated with infertility and reduced life expectancy. Most cases are idiopathic, and a genetic…

Date: 2025-12-11

The role of macrophages in the mitigation by decitabine of acute allograft rejection

Abstract: We have recently shown that the DNA hypomethylating agent decitabine (DAC) rescues lung allografts from acute rejection. This involves a mechanism that is dependent on…

Date: 2025-12-11

Effectiveness and safety of ultrasound-guided stellate ganglion block in C57BL/6 mice

Abstract: Stellate ganglion block (SGB) is a unique anesthetic procedure distinguished by rapid onset, precise effects, and repeatability. The advent of ultrasound guidance has…

Date: 2025-12-11

Therapeutic drug monitoring plays an important role in patients with noninfectious uveitis receiving adalimumab

Abstract: To evaluate the association between serum adalimumab (ADA) concentrations, antibodies against adalimumab (AAAs), tumor necrosis factor ? (TNF?) levels, and clinical…

Date: 2025-12-11

Association between CRP-TyG index and hepatic synthetic function in post-myocardial infarction ICU patients

Abstract: To determine whether the CRP–TyG index (CTI)—a composite of systemic inflammation and insulin resistance—is independently associated with early hepatic synthetic…

Date: 2025-12-11

Development, validation, and web deployment of a rebleeding risk prediction model for acute non-variceal upper gastrointestinal bleeding in a Chinese population

Abstract: Acute non-variceal upper gastrointestinal bleeding (ANVUGIB) is a common life-threatening emergency. Despite advances in endoscopic hemostasis, the 7-day rebleeding rate…

Date: 2025-12-11

Helicobacter pylori infection and its impact on metabolic dysfunction-associated steatotic liver disease: a mediation analysis of neutrophil-albumin ratio

Abstract: Helicobacter pylori , a widely found bacterium, has been controversially connected to the risk of metabolic dysfunction-associated steatotic liver disease (MASLD). How…

Date: 2025-12-11

Glymphatic dysfunction in neuromyelitis optica spectrum disorder

Abstract: Neuromyelitis optica spectrum disorder (NMOSD) involves aquaporin-4-mediated astrocyte injury, potentially impairing the glymphatic system. We assessed glymphatic…

Date: 2025-12-11

Tertiary lymphoid structure drives allograft rejection via IFN-?-JAK-STAT-dependent atypical memory B cell differentiation

Abstract: Tertiary lymphoid structure (TLS) is a neogenized, ectopic lymphoid aggregate found in infected, autoimmune and tumour tissues with an activated adaptive immune…

Date: 2025-12-11