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Baseline AHR expression shapes immune response to pharmacological modulation in PBMCs from pancreatic cancer patients

Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immunotherapy because of its highly immunosuppressive tumor microenvironment. Aryl hydrocarbon…

Date: 2025-11-20

Delayed-onset parkinsonism is common after isolated striatal infarcts

Abstract: While case studies have suggested that only a minority of patients with putaminal lesions develop parkinsonism, existing data are limited by involvement of adjacent…

Date: 2025-11-20

Radiation-induced eCIRP causes macrophage phagocytic dysfunction via mitochondrial impairment and ferroptosis

Abstract: Ionizing radiation causes immune dysfunction, increasing susceptibility to infection and mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) is released…

Date: 2025-11-20

Low lymphozyte pool, colon perforation and hydrocephalus as clinical features in an infant with a postzygotic PIK3CA variant

Abstract: Pathogenic variants in the PIK3CA gene, which encodes the p110-? catalytic subunit of the phosphoinositide 3-kinase (PI3K), are commonly associated with overgrowth…

Date: 2025-11-20

R3HDM4 influences kidney renal clear cell carcinoma progression, immune modulation, and potential links to the IGSF8 immune checkpoint

Abstract: R3HDM4, or R3H domain containing 4, is a gene with uncertain functions but is frequently investigated for its potential cellular roles and associations with various…

Date: 2025-11-19

Dosimetric parameter determination of a carbon-nanotube based miniature x-ray tube for HDR brachytherapy

Abstract: This study aims to determine key dosimetric parameters of a vacuum-sealed miniature X-ray tube (mXT) equipped with a carbon nanotube field emitter for application in HDR…

Date: 2025-11-19

Establishment and validation of a prognostic model for nasopharyngeal carcinoma patients based on partial response rates

Abstract: This study aims to investigate the impact of varying rates of partial response (PR) on survival outcomes in nasopharyngeal carcinoma (NPC) patients following induction…

Date: 2025-11-19

Oligocentric Castleman disease: clinical characteristics and surgical outcomes from a single-centre retrospective study

Abstract: Oligocentric Castleman Disease (OCD), a distinct subtype of Castleman Disease (CD) intermediate between Unicentric (UCD) and idiopathic Multicentric (iMCD) forms,…

Date: 2025-11-19

Pan-cancer landscape of UBD/FAT10 and experimental validation in esophageal carcinoma

Abstract: To comprehensively characterize the pan-cancer roles of Ubiquitin D (UBD/FAT10) in tumorigenesis, immune regulation, and therapeutic response through integrative…

Date: 2025-11-19

The prognostic value of pretreatment inflammatory and nutrition-related indices in patients with cardia cancer

Abstract: To evaluate the prognostic significance of inflammatory and nutrition-related indexes in patients with cardia cancer prior to treatment. A total of 229 patients with…

Date: 2025-11-19