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A novel CTLA-4 deletion variant in a child with refractory autoimmune hemolytic anemia: molecular and functional characterization

Abstract: As a critical immune checkpoint, cytotoxic T-lymphocyte-associated protein 4( CTLA-4 )deficiency is a well-established cause of inborn errors of immunity. This study…

Date: 2025-11-19

CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors

Abstract: PARP inhibitors are widely used class of drugs for the treatment of homologous recombination deficient cancers, including BRCA mutated ones. These drugs led to…

Date: 2025-11-19

Higher prevalence of short stature and excess weight in children with sleep disorders

Abstract: Sleep disorders are common in childhood and are recognized as a significant public health concern, particularly due to their association with childhood obesity. However,…

Date: 2025-11-19

The impact of a value-based hospital-community-family linkage program on blood glucose management and hypoglycemia in elderly diabetic patients: a randomized controlled trial

Abstract: The management of elderly type 2 diabetes (T2DM) presents significant challenges, with the risk of hypoglycemia being particularly prominent. This risk severely impacts…

Date: 2025-11-19

Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion

Abstract: Current screening methods for hypercortisolism face limitations in clinical practice. Our study proposes and validates a novel biomarker, the morning spot urinary…

Date: 2025-11-19

Yes-associated protein regulates autophagy to restore skin barrier function in atopic dermatitis

Abstract: Atopic dermatitis (AD) is characterized by skin barrier dysfunction and inflammation.This study explored the relationship between Yes-associated protein (YAP)…

Date: 2025-11-19

Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis

Abstract: Pathogenic variants in ALOX12B , a crucial enzyme involved in epidermal lipid processing, are among the most common causes of autosomal recessive congenital ichthyosis…

Date: 2025-11-19

Neuromedin B identified as a therapeutic target for atopic dermatitis: evidence from Mendelian randomization and PCR validation

Abstract: Atopic dermatitis (AD) is a long-standing inflammatory dermatosis marked by intense itching and immune imbalance. Despite recent advances in targeted biologic therapies,…

Date: 2025-11-19

CIK-augmented anti-PD1/CTLA4 immunotherapy eradicates chemo-resistant ovarian cancer via tripartite mechanistic synergy

Abstract: Immune checkpoint inhibitors (ICIs) combined with adoptive cell therapy represent promising strategies against ovarian cancer, yet their synergistic mechanisms remain…

Date: 2025-11-19

Impact of smoking exposure on meibomian gland morphology and tear film stability: a cross-sectional study

Abstract: To investigate the effects of smoking on the structure and function of the meibomian glands. A total of 104 chronic smokers (with a smoking history of more than 5?years)…

Date: 2025-11-19