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Efficacy and safety of the third-generation tyrosine kinase inhibitor Olverembatinib in relapsed and persistent minimal residual disease positive Philadelphia chromosome-positive acute lymphoblastic leukemia patients

Abstract: This study aimed to evaluate the efficacy of Olverembatinib in patients with relapsed and persistent minimal residual disease-positive Philadelphia chromosome-positive…

Date: 2025-10-03

Improvement of revised international staging system risk stratification in patients with newly diagnosed multiple myeloma using a high bone marrow plasma cell percentage: a real-world study in China

Abstract: Multiple myeloma (MM) is a heterogeneous malignant plasma cell neoplasm. A significant increase in the bone marrow plasma cell percentage (BMPC%) may adversely affect…

Date: 2025-10-03

Development and testing of an online course on the second victim phenomenon: a three-dimensional evaluation and proof of concept

Abstract: The Second Victim Phenomenon (SVP) refers to the emotional, psychological, and professional consequences healthcare professionals (HCPs) may face following adverse…

Date: 2025-10-03

Treatment of benign lesions of the proximal femur in young pediatric patients using adult 3.5 mm proximal humerus locking plates

Abstract: This study aimed to assess the efficacy of using adult 3.5 mm proximal humerus locking plates (PHLPs) for treating benign proximal femur lesions in skeletally immature…

Date: 2025-10-03

Toll-like receptor activation and gene delivery efficiency in canine dendritic cells: a model for comparative oncology

Abstract: Dendritic cells (DCs) are pivotal antigen-presenting cells capable of bridging innate and adaptive immunity, making them promising candidates for cancer immunotherapy.…

Date: 2025-10-03

Next-generation sequencing-based genomic profiling of advanced soft tissue and bone sarcomas

Abstract: Sarcomas are rare mesenchymal tumors classified into soft tissue (STS) and bone sarcomas. Despite advances in treatment, the 5-year survival rate for metastatic disease…

Date: 2025-10-03

Development and validation of a predictive model for severe radiation-induced esophagitis in lung cancer patients undergoing moderate hypofractionated radiotherapy

Abstract: Moderate hypofractionated radiotherapy (MHRT) is an important treatment modality for lung cancer, offering shorter courses and improved local control, yet it also…

Date: 2025-10-03

Immune checkpoint inhibitor-associated aseptic meningitis: a pharmacovigilance study using the FDA adverse event reporting system (2011–2024)

Abstract: Immune checkpoint inhibitors (ICIs) are pivotal in oncology but carry risks of immune-related adverse events (irAEs). Aseptic meningitis (AM) represents a serious…

Date: 2025-10-03

Machine learning–based insights into circulating autoantibody dynamics and treatment outcomes in patients with NSCLC receiving immune checkpoint inhibitors

Abstract: Immune checkpoint inhibitors (ICIs) targeting the programmed death-1/ligand-1 (PD-1/PD-L1) axis have significantly improved treatment outcomes in non-small cell lung…

Date: 2025-10-03

The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population

Abstract: Gallbladder cancer (GBC) is a highly aggressive malignancy with one of the highest incidence rates reported in Chile. Despite its clinical impact, molecular…

Date: 2025-10-03