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Toll-like receptor activation and gene delivery efficiency in canine dendritic cells: a model for comparative oncology

Abstract: Dendritic cells (DCs) are pivotal antigen-presenting cells capable of bridging innate and adaptive immunity, making them promising candidates for cancer immunotherapy.…

Date: 2025-10-03

Next-generation sequencing-based genomic profiling of advanced soft tissue and bone sarcomas

Abstract: Sarcomas are rare mesenchymal tumors classified into soft tissue (STS) and bone sarcomas. Despite advances in treatment, the 5-year survival rate for metastatic disease…

Date: 2025-10-03

Development and validation of a predictive model for severe radiation-induced esophagitis in lung cancer patients undergoing moderate hypofractionated radiotherapy

Abstract: Moderate hypofractionated radiotherapy (MHRT) is an important treatment modality for lung cancer, offering shorter courses and improved local control, yet it also…

Date: 2025-10-03

Immune checkpoint inhibitor-associated aseptic meningitis: a pharmacovigilance study using the FDA adverse event reporting system (2011–2024)

Abstract: Immune checkpoint inhibitors (ICIs) are pivotal in oncology but carry risks of immune-related adverse events (irAEs). Aseptic meningitis (AM) represents a serious…

Date: 2025-10-03

Machine learning–based insights into circulating autoantibody dynamics and treatment outcomes in patients with NSCLC receiving immune checkpoint inhibitors

Abstract: Immune checkpoint inhibitors (ICIs) targeting the programmed death-1/ligand-1 (PD-1/PD-L1) axis have significantly improved treatment outcomes in non-small cell lung…

Date: 2025-10-03

The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population

Abstract: Gallbladder cancer (GBC) is a highly aggressive malignancy with one of the highest incidence rates reported in Chile. Despite its clinical impact, molecular…

Date: 2025-10-03

Development, feasibility and usability of an app for the correct nutrition of children and adolescents with acute lymphoblastic leukemia

Abstract: Proper nutrition during cancer treatment is crucial for children and adolescents with acute lymphoblastic leukemia (ALL), as malnutrition can impact treatment tolerance,…

Date: 2025-10-02

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

Abstract: IRM appears promising and well tolerated as first-line therapy for newly diagnosed PCNS DLBCL in a small pilot cohort; these hypothesis-generating results require…

Date: 2025-10-02

Noninvasive estimation of oxygenation index in pediatric critical care: an independent retrospective observational validation

Abstract: To independently validate an empirically optimized algorithm for calculating estimated Oxygenation Index (eOI) using noninvasive parameters from pediatric intensive care…

Date: 2025-10-02

Knowledge, attitudes, and practices toward assisted reproductive technology and painless egg retrieval among infertile women in the northwest region of China

Abstract: With the increasing use of assisted reproductive technology (ART) as a solution for infertility, understanding patient knowledge, attitudes, and practices (KAP) is…

Date: 2025-10-02