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CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint

Abstract: Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence…

Date: 2025-10-02

Predictive modeling of acute radiation-induced dermatitis in nasopharyngeal carcinoma patients undergoing tomotherapy using machine learning with multimodal data integration

Abstract: Radiation dermatitis (RD) is a common and debilitating side effect of radiotherapy in nasopharyngeal carcinoma (NPC) patients. Traditional predictive models lack…

Date: 2025-10-02

Glycolysis-related radiosensitivity signature for predicting radiotherapy response in breast cancer

Abstract: This study investigates the influence of glycolytic activity on the efficacy of radiotherapy in breast cancer (BRCA) patients, aiming to develop a glycolysis-related…

Date: 2025-10-02

Multi-omics analyses inform mechanisms of immunotherapy response in pancreatic cancer

Abstract: Pancreatic ductal adenocarcinoma (PDAC) continues to exhibit resistance to immunotherapy. In this study, we evaluated the efficacy of combining immunotherapy with…

Date: 2025-10-02

Integrative multidimensional analysis of age-associated synthetic lethal genes and development of a prognostic model in breast cancer

Abstract: Breast cancer (BRCA) is the most common malignancy and leading cause of mortality among women, with rising incidence in younger patients. Although treatments have…

Date: 2025-10-02

Chinese version and application of the global health competencies survey for healthcare professionals

Abstract: This study aimed to introduce and validate the global health competencies survey (GHCS) in the Chinese healthcare context, addressing the need for a comprehensive tool…

Date: 2025-10-01

Nutritional status indices on the prognosis of patients with relapsed and refractory multiple myeloma treated with CAR-T cell immunotherapy

Abstract: Chimeric antigen receptor (CAR) T-cell therapy shows remarkable efficacy against relapsed/refractory multiple myeloma (R/R MM). Nutritional status, assessed by objective…

Date: 2025-10-01

Development and application of machine learning models for hematological disease diagnosis using routine laboratory parameters: a user-friendly diagnostic platform

Abstract: In recent years, with the change of social environment, the incidence and detection rate of hematological diseases have shown an increasing trend. Early diagnosis and…

Date: 2025-10-01

High-content stimulated Raman pathology imaging and transcriptomics reveal leukemia subtype-specific lipid metabolic heterogeneity

Abstract: Leukemia, a heterogeneous group of hematological malignancies, is characterized by abnormal proliferation of immature hematopoietic cells. Current diagnostics primarily…

Date: 2025-10-01