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The relationship between number of pregnancies and serum 25-hydroxyvitamin D levels in women with a prior pregnancy: a cross - sectional analysis, machine learning - based prediction model, and SHAP - assisted feature importance evaluation

Abstract: The primary aim of this study is to explore the association between gravidity and serum 25-hydroxyvitamin D [25(OH)D] levels in women, as existing research rarely…

Date: 2025-09-22

Efficacy and safety of immune checkpoint inhibitor rechallenge therapy in the treatment of advanced acquired immune-resistant non-small cell lung cancer: a retrospective study

Abstract: Patients with advanced non-small cell lung cancer who have failed first-line immunotherapy and lack driver gene mutations face limited options for subsequent treatment.…

Date: 2025-09-22

Changes in T lymphocyte subsets in patients with acute neuromyelitis optica spectrum disorder

Abstract: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the central nervous system, primarily characterized by anti-AQP4 antibodies. While,…

Date: 2025-09-22

Use of a digital rescue inhaler and at-home spirometer among inner-city children with asthma: a real-world experience

Abstract: Across all age groups, asthma disproportionally affects inner-city underserved populations. Studies on the use of at-home spirometry and digital inhalers have limited…

Date: 2025-09-22

Humoral response induced after intranasal vaccination with heat inactivated Acinetobacter baumannii protects immunodeficient mice against hypervirulent LAC-4 strain

Abstract: Acinetobacter baumannii is an opportunistic bacterium that causes serious nosocomial infections, including pneumonia and bacteremia, especially in immunocompromised…

Date: 2025-09-22

Sex-dependent modulation of acute respiratory distress syndrome by Bacteroides acidifaciens : gut microbiome impact on lung inflammation

Abstract: Bacteroides acidifaciens (BA), a common gut commensal, is known to modulate immune responses, but its role in acute respiratory distress syndrome (ARDS) and potential…

Date: 2025-09-22

Preclinical in vivo evaluation of a gonococcal multivalent vaccine containing antigens identified by CASS

Abstract: Neisseria gonorrhoeae , causative agent of the human sexually transmitted infection gonorrhea, is a significant global health concern because of increasing antimicrobial…

Date: 2025-09-22

Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth

Abstract: RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-?B activation through the assembly of…

Date: 2025-09-22

Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response

Abstract: Pregnancy is a complex process that requires a tightly regulated immune environment to support fetal development and protect against infections. The main barrier between…

Date: 2025-09-22

Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients

Abstract: In severe COVID-19, direct-acting antiviral drugs were not effective in hyperinflammatory stages and steroid treatment may weaken host immunity. The MEK inhibitor…

Date: 2025-09-22